SCOPIT: sample size calculations for single-cell sequencing experiments

Sample-Size Calculations for Cohen's Kappa

In recent years, researchers in the psychosocial and biomedical sciences have become increasingly aware of the importance of sample-size calculations in the design of research projects. Such considerations are, however, rarely applied for studies involving agreement of raters. Published results on this topic are limited and generally provide rather complex formulas. In addition, they generally ...

Sample size calculations for randomized controlled trials.

Most informed consent documents for randomized controlled trials implicitly or explicitly promise the prospective participant that the trial has a reasonable chance of answering a medically important question. The medical literature, however, is replete with descriptions of trials that provided equivocal answers to the questions they addressed. Papers describing the results of such studies may ...

Sample size calculations for skewed distributions

BACKGROUND Sample size calculations should correspond to the intended method of analysis. Nevertheless, for non-normal distributions, they are often done on the basis of normal approximations, even when the data are to be analysed using generalized linear models (GLMs). METHODS For the case of comparison of two means, we use GLM theory to derive sample size formulae, with particular cases bei...

Pilot Experiments for Metagenomic Sample Sequencing

Sample size calculations for population pharmacodynamic experiments involving repeated dichotomous observations.

Analysis of repeated binary measurements presents a challenge in terms of the correlation between measurements within an individual and a mixed-effects modelling approach has been used for the analysis of such data. Sample size calculation is an important part of clinical trial design and it is often based on the method of analysis. We present a method for calculating the sample size for repeat...